Production of mycarosyl protylonolide by a mycaminose idiotroph from the tylosin-producing strain Streptomyces fradiae KA-427.
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چکیده
منابع مشابه
Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae.
Protylonolide is a lactonic precursor of tylosin aglycone, produced by a mutant of Streptomyces fradiae. It originates from n-butyrate, propionate and acetate units. Studies were carried out using a protylonolide-producing mutant on the correlation between protylonolide biosynthesis, regulation by NH4+ and amino acid metabolism. Protylonolide production decreased in a defined medium containing ...
متن کاملHybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms.
Biotransformation of a macrolide antibiotic and a related compound was studied using various macrolide-producing microorganisms grown in the presence of cerulenin, an inhibitor of de novo synthesis of the aglycone moiety. Protylonolide (1) was transformed into 5-O-(4'-O-propionylmycarosyl)protylonolide (2) by a leucomycin-producing strain, Streptoverticillium kitasatoensis KA-429. M-4365 G2 (3)...
متن کاملNovel fermentation products from Streptomyces fradiae: X-ray crystal structure of 5-O-mycarosyltylactone and proof of the absolute configuration of tylosin.
5-O-Mycarosyltylactone has been isolated as a predominant factor from fermentation broths of a Streptomyces fradiae mutant. The relative configurations of mycarose and tylactone (protylonolide) have been determined by X-ray crystal structure analysis. Hydrolysis of 5-O-mycarosyltylactone yielded (-)-tylactone and L-(-)-mycarose. Taken together, these two experiments establish the absolute confi...
متن کاملChimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.
Sir: Microbial conversion of antibiotically inactive macrocyclic lactones to active compounds is an important approach in the search for new macrolide antibiotics. Mutational biosynthesis originally proposed by SHIER et al.1) was proved useful also for constructing new macrolide antibiotics and many new derivatives were obtained. However, these were virtually inactive,2-1) or weakly active and ...
متن کاملElucidation of structure of novel macrolide antibiotics produced by mutant strains of Streptomyces fradiae.
Tylosin is a 16-membered macrolide antibiotic which is produced commercially by strains of Streptomyces fradiae'•1' and is composed of a substituted lactone (tylonolide), an amino sugar (mycaminose) and two neutral sugars (mycinose, mycarose)'). Recently, a series of mutants of S. fi•adiae which are blocked in specific steps in the biosynthesis of tylosin has been described". From an analysis o...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 33 8 شماره
صفحات -
تاریخ انتشار 1980